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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRKAR1A All Species: 39.7
Human Site: Y175 Identified Species: 62.38
UniProt: P10644 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10644 NP_002725.1 381 42982 Y175 G D E G D N F Y V I D Q G E T
Chimpanzee Pan troglodytes XP_511647 260 29299 S83 D S R E D E I S P P P P N P V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537577 381 43019 Y175 G D E G D N F Y V I D Q G E M
Cat Felis silvestris
Mouse Mus musculus Q9DBC7 381 43167 Y175 G D E G D N F Y V I D Q G E M
Rat Rattus norvegicus P09456 381 43076 Y175 G D E G D N F Y V I D Q G E M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509586 626 69567 Y420 G D E G D N F Y V V D Q G E M
Chicken Gallus gallus Q5ZM91 382 43332 Y176 G D E G D N F Y V V D Q G E M
Frog Xenopus laevis NP_001085084 381 43157 Y175 G D E G D N F Y V V D Q G E M
Zebra Danio Brachydanio rerio NP_001017732 379 43009 Y173 G D E G D N F Y V I D Q G E M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P16905 376 42221 Y170 G D E G D N F Y V I D V G E V
Honey Bee Apis mellifera XP_396167 372 41646 T183 F V N G E L A T T I G E G G S
Nematode Worm Caenorhab. elegans P30625 366 41449 N172 G T V D V Y V N H E Y V L T I
Sea Urchin Strong. purpuratus Q26619 369 41770 D180 N K V G A Y K D S G S F G E L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07278 416 47201 Y222 G D Q G D Y F Y V V E K G T V
Red Bread Mold Neurospora crassa Q01386 385 42138 S181 R F E V Y V N S T G A L Q P G
Conservation
Percent
Protein Identity: 100 68.2 N.A. 97.9 N.A. 96.8 97.3 N.A. 58.7 92.4 92.6 91.5 N.A. 71.3 74 57.7 39.3
Protein Similarity: 100 68.2 N.A. 98.1 N.A. 97.3 98.4 N.A. 60 96 95.8 95.8 N.A. 81.6 85.3 73.4 56.9
P-Site Identity: 100 6.6 N.A. 93.3 N.A. 93.3 93.3 N.A. 86.6 86.6 86.6 93.3 N.A. 86.6 20 6.6 20
P-Site Similarity: 100 6.6 N.A. 93.3 N.A. 93.3 93.3 N.A. 93.3 93.3 93.3 93.3 N.A. 86.6 40 6.6 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 31.2 34
Protein Similarity: N.A. N.A. N.A. N.A. 50.7 52.4
P-Site Identity: N.A. N.A. N.A. N.A. 53.3 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 80 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 7 0 7 0 0 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 67 0 7 74 0 0 7 0 0 60 0 0 0 0 % D
% Glu: 0 0 67 7 7 7 0 0 0 7 7 7 0 67 0 % E
% Phe: 7 7 0 0 0 0 67 0 0 0 0 7 0 0 0 % F
% Gly: 74 0 0 80 0 0 0 0 0 14 7 0 80 7 7 % G
% His: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 7 0 0 47 0 0 0 0 7 % I
% Lys: 0 7 0 0 0 0 7 0 0 0 0 7 0 0 0 % K
% Leu: 0 0 0 0 0 7 0 0 0 0 0 7 7 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 47 % M
% Asn: 7 0 7 0 0 60 7 7 0 0 0 0 7 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 7 7 7 7 0 14 0 % P
% Gln: 0 0 7 0 0 0 0 0 0 0 0 54 7 0 0 % Q
% Arg: 7 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 7 0 0 0 0 0 14 7 0 7 0 0 0 7 % S
% Thr: 0 7 0 0 0 0 0 7 14 0 0 0 0 14 7 % T
% Val: 0 7 14 7 7 7 7 0 67 27 0 14 0 0 20 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 20 0 67 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _